Assassin

Assassins are highly aggressive, focused, damage dealers, better for hit and run skirmishes then drawn out tanking or back-line sieges.

Always remember, when choosing secondary skills, that native skills often have better synergy with the profession's purpose, interact better with the profession's other skills, and benefit from runes.

Warrior

- Skills such as "Fear Me!" syngergize with the extra adrenaline from fast dagger attacks.
- Assassins do not have any attack speed enhancing skills. Flurry, Flail and Tiger Stance can increase DPS. (Damage Per Second)
- Wild Blow can be a good choice for Assassins to remove defensive stances in a clutch.

Ranger

- Barrage damage can be improved with high critical strikes attributes, adding bonus damage to attacks, energy bonus, and effects from skills like Critical Eye, if you use Barrage with Sharpen Daggers, you can spread bleeding in mobs.
- Disrupting Accuracy can be combined with critical-enhancing skills such as Way of the Assassin to provide constant interrupts.
- Apply Poison can offer a more reliable means of poisoning opponents in conjunction with Signet of Toxic Shock and the elite Seeping Wound

Elementalist

- The knockdown from Shock can drive an attack chain, though it is no longer as popular as other skills such as hexes to drive the attack chain.
- The Conjure line of enchantments can increase damage with the assassin's high attack rate.

Mesmer

- Arcane Echo can be used to chain Shadow Form when running.

Monk

- The Protection Prayers skill Mending Touch is a good spell to remove risky conditions.

Necromancer

- Curses hex spells, particularly Parasitic Bond, can be used to drive many attack chains.

Ritualist

- Sparing use of weapon spells such as Warmonger's Weapon can aid an Assassin in battle, although weapon spamming is best left to Ritualist primaries.

Paragon

- If you use the skill "Go for the Eyes!" it will drastically increase your chance to critical and get the energy gain. It is also benificial because you do not need adrenaline for Assassins.

Dervish

- The Assassin Dervish can use Critical Strikes to greatly improve the Critical Hit rate with a scythe.